Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity.

Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity.

Evaluation of: Yan M, Callahan CA, Beyer JC et al.: Chronic DLL4 blockade induces vascular neoplasms. Nature 463, E6-E7 (2010). Delta-like ligand 4 (DLL4) is a Notch ligand that is critical in the formation of a functional vascular network in tumors. Blockade of DLL4-mediated Notch signaling strikin...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Li, J, Jubb, A, Harris, A
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2010

समान संसाधन

Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer.
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प्रकाशित: (2009)

Dll4/Notch Signaling Pathway and Tumor Angiogenesis
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प्रकाशित: (2009-11-01)

DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.
द्वारा: Li, J, और अन्य
प्रकाशित: (2011)

DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo
द्वारा: Li, J, और अन्य
प्रकाशित: (2011)

Expression of DLL4 and VEGF in Lung Adenocarcinoma and their Relationship with Angiogenesis in Tumor
द्वारा: Xiaoping LI, और अन्य
प्रकाशित: (2009-02-01)

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.
द्वारा: Kristina Preuße, और अन्य
प्रकाशित: (2015-06-01)

Down regulating Delta-4 (DLL4) using RNA interference - a potential future treatment for bladder cancer
द्वारा: Patel, N, और अन्य
प्रकाशित: (2005)

Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine
द्वारा: Hiromichi Shimizu, और अन्य
प्रकाशित: (2014-05-01)

Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis?
द्वारा: Sainson, R, और अन्य
प्रकाशित: (2007)

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis
द्वारा: Liu Ren, और अन्य
प्रकाशित: (2010-11-01)

Parit-parit [dll.]

Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
द्वारा: Geffers, I, और अन्य
प्रकाशित: (2007)

Polyethylenimine Triggers Dll4 Degradation to Regulate Angiogenesis In Vitro
द्वारा: Binghua Cheng, और अन्य
प्रकाशित: (2024-02-01)

DLL3: an emerging target in small cell lung cancer
द्वारा: Dwight H. Owen, और अन्य
प्रकाशित: (2019-06-01)

Targeting CD47-SIRPa axis shows potent preclinical anti-tumor activity as monotherapy and synergizes with PARP inhibition
द्वारा: Hussein Al-Sudani, और अन्य
प्रकाशित: (2023-07-01)

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro
द्वारा: Lena Tveriakhina, और अन्य
प्रकाशित: (2018-10-01)

Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells.
द्वारा: Harrington, L, और अन्य
प्रकाशित: (2008)

Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis.
द्वारा: Carla Real, और अन्य
प्रकाशित: (2011-01-01)

The potential value of Notch1 and DLL1 in the diagnosis and prognosis of patients with active TB
द्वारा: Jinling Xie, और अन्य
प्रकाशित: (2023-03-01)

The role of DLL4-NOTCH signalling in endothelial cell metabolism
द्वारा: Harjes, U
प्रकाशित: (2014)

RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain
द्वारा: Bridges, E, और अन्य
प्रकाशित: (2020)

The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions
द्वारा: Ivan Lobov, और अन्य
प्रकाशित: (2018-01-01)

Moving beyond hydroxychloroquine: the novel lysosomal autophagy inhibitor ROC-325 shows significant potential in preclinical studies
द्वारा: Trace M. Jones, और अन्य
प्रकाशित: (2019-11-01)

The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis.
द्वारा: Bridge, G, और अन्य
प्रकाशित: (2012)

The Regulation of para-Nitrophenol Degradation in Pseudomonas putida DLL-E4.
द्वारा: Qiongzhen Chen, और अन्य
प्रकाशित: (2016-01-01)

1189 Elucidating the effects of chemotherapy and immune checkpoint blockade on the activity of tarlatamab, a DLL3-targeting bispecific T cell engager molecule, in small cell lung cancer preclinical models
द्वारा: Keegan Cooke, और अन्य
प्रकाशित: (2023-11-01)

Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues.
द्वारा: Martinez, J, और अन्य
प्रकाशित: (2009)

MItra Bestari, Petunjuk penulisan, dll
द्वारा: DPPM Editor
प्रकाशित: (2016-03-01)

Petunjuk penulisan, MItra Bestari, dll
द्वारा: DPPM Editor
प्रकाशित: (2016-03-01)

MPDZ promotes DLL4-induced Notch signaling during angiogenesis
द्वारा: Fabian Tetzlaff, और अन्य
प्रकाशित: (2018-04-01)

Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer
द्वारा: Yoshitaka Isobe, और अन्य
प्रकाशित: (2020-02-01)

Rovalpituzumab Tesirine: A Novel DLL3-Targeting Antibody–Drug Conjugate
द्वारा: Bilal H. Lashari, और अन्य
प्रकाशित: (2018-09-01)

Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers
द्वारा: Alexandra D. Dreyfuss, और अन्य
प्रकाशित: (2022-10-01)

Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer
द्वारा: Lin Wang, और अन्य
प्रकाशित: (2023-02-01)

Jambatan Pulau Pinang : himpunan sajak, cerpen, dll /
द्वारा: 408021 Zainal Abidin S. A. M. Jamalullail
प्रकाशित: (1990)

Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
द्वारा: Nan W. Hultgren, और अन्य
प्रकाशित: (2020-10-01)

630 PD-L1/CD47 tumor directed B-BodyTM bispecific antibodies demonstrating significant anti-tumor activity with no toxicity in preclinical models
द्वारा: Peter Lamb, और अन्य
प्रकाशित: (2020-11-01)

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice.
द्वारा: Mike L J Jeurissen, और अन्य
प्रकाशित: (2016-01-01)

Analysis of a DS-CDMA receiver DLL architecture
द्वारा: Moss, J, और अन्य
प्रकाशित: (1996)

Exploring the expression of DLL3 in gastroenteropancreatic neuroendocrine neoplasms and its potential diagnostic value
द्वारा: L. Yin, और अन्य
प्रकाशित: (2025-01-01)