Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity.

Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity.

Evaluation of: Yan M, Callahan CA, Beyer JC et al.: Chronic DLL4 blockade induces vascular neoplasms. Nature 463, E6-E7 (2010). Delta-like ligand 4 (DLL4) is a Notch ligand that is critical in the formation of a functional vascular network in tumors. Blockade of DLL4-mediated Notch signaling strikin...

書誌詳細
主要な著者:	Li, J, Jubb, A, Harris, A
フォーマット:	Journal article
言語:	English
出版事項:	2010

類似資料

Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer.
著者:: Jubb, A, 等
出版事項: (2009)

Dll4/Notch Signaling Pathway and Tumor Angiogenesis
著者:: Xinyu DING, 等
出版事項: (2009-11-01)

DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.
著者:: Li, J, 等
出版事項: (2011)

DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo
著者:: Li, J, 等
出版事項: (2011)

Expression of DLL4 and VEGF in Lung Adenocarcinoma and their Relationship with Angiogenesis in Tumor
著者:: Xiaoping LI, 等
出版事項: (2009-02-01)

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.
著者:: Kristina Preuße, 等
出版事項: (2015-06-01)

Down regulating Delta-4 (DLL4) using RNA interference - a potential future treatment for bladder cancer
著者:: Patel, N, 等
出版事項: (2005)

Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine
著者:: Hiromichi Shimizu, 等
出版事項: (2014-05-01)

Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis?
著者:: Sainson, R, 等
出版事項: (2007)

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis
著者:: Liu Ren, 等
出版事項: (2010-11-01)

Parit-parit [dll.]

Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
著者:: Geffers, I, 等
出版事項: (2007)

Polyethylenimine Triggers Dll4 Degradation to Regulate Angiogenesis In Vitro
著者:: Binghua Cheng, 等
出版事項: (2024-02-01)

Targeting CD47-SIRPa axis shows potent preclinical anti-tumor activity as monotherapy and synergizes with PARP inhibition
著者:: Hussein Al-Sudani, 等
出版事項: (2023-07-01)

DLL3: an emerging target in small cell lung cancer
著者:: Dwight H. Owen, 等
出版事項: (2019-06-01)

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro
著者:: Lena Tveriakhina, 等
出版事項: (2018-10-01)

Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells.
著者:: Harrington, L, 等
出版事項: (2008)

Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis.
著者:: Carla Real, 等
出版事項: (2011-01-01)

The potential value of Notch1 and DLL1 in the diagnosis and prognosis of patients with active TB
著者:: Jinling Xie, 等
出版事項: (2023-03-01)

The role of DLL4-NOTCH signalling in endothelial cell metabolism
著者:: Harjes, U
出版事項: (2014)

RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain
著者:: Bridges, E, 等
出版事項: (2020)

The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions
著者:: Ivan Lobov, 等
出版事項: (2018-01-01)

Moving beyond hydroxychloroquine: the novel lysosomal autophagy inhibitor ROC-325 shows significant potential in preclinical studies
著者:: Trace M. Jones, 等
出版事項: (2019-11-01)

The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis.
著者:: Bridge, G, 等
出版事項: (2012)

The Regulation of para-Nitrophenol Degradation in Pseudomonas putida DLL-E4.
著者:: Qiongzhen Chen, 等
出版事項: (2016-01-01)

1189 Elucidating the effects of chemotherapy and immune checkpoint blockade on the activity of tarlatamab, a DLL3-targeting bispecific T cell engager molecule, in small cell lung cancer preclinical models
著者:: Keegan Cooke, 等
出版事項: (2023-11-01)

Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues.
著者:: Martinez, J, 等
出版事項: (2009)

MItra Bestari, Petunjuk penulisan, dll
著者:: DPPM Editor
出版事項: (2016-03-01)

Petunjuk penulisan, MItra Bestari, dll
著者:: DPPM Editor
出版事項: (2016-03-01)

MPDZ promotes DLL4-induced Notch signaling during angiogenesis
著者:: Fabian Tetzlaff, 等
出版事項: (2018-04-01)

Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer
著者:: Yoshitaka Isobe, 等
出版事項: (2020-02-01)

Rovalpituzumab Tesirine: A Novel DLL3-Targeting Antibody–Drug Conjugate
著者:: Bilal H. Lashari, 等
出版事項: (2018-09-01)

Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers
著者:: Alexandra D. Dreyfuss, 等
出版事項: (2022-10-01)

Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer
著者:: Lin Wang, 等
出版事項: (2023-02-01)

Jambatan Pulau Pinang : himpunan sajak, cerpen, dll /
著者:: 408021 Zainal Abidin S. A. M. Jamalullail
出版事項: (1990)

Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
著者:: Nan W. Hultgren, 等
出版事項: (2020-10-01)

630 PD-L1/CD47 tumor directed B-BodyTM bispecific antibodies demonstrating significant anti-tumor activity with no toxicity in preclinical models
著者:: Peter Lamb, 等
出版事項: (2020-11-01)

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice.
著者:: Mike L J Jeurissen, 等
出版事項: (2016-01-01)

Analysis of a DS-CDMA receiver DLL architecture
著者:: Moss, J, 等
出版事項: (1996)

Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential
著者:: Rosa A. van Amerongen, 等
出版事項: (2023-03-01)