Rare protein-truncating variants in APOB, lower low-density lipoprotein cholesterol, and protection against coronary heart disease
BACKGROUND:Familial hypobetalipoproteinemia (FHBL) is a genetic disorder caused by rare protein-truncating variants (PTV) in the gene encoding apolipoprotein B ( APOB), the major protein component of low-density and triglyceride-rich lipoprotein particles. Whether heterozygous APOB deficiency is ass...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Journal article |
Language: | English |
Published: |
Wolters Kluwer Health
2019
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