Rare protein-truncating variants in APOB, lower low-density lipoprotein cholesterol, and protection against coronary heart disease

Rare protein-truncating variants in APOB, lower low-density lipoprotein cholesterol, and protection against coronary heart disease

BACKGROUND:Familial hypobetalipoproteinemia (FHBL) is a genetic disorder caused by rare protein-truncating variants (PTV) in the gene encoding apolipoprotein B ( APOB), the major protein component of low-density and triglyceride-rich lipoprotein particles. Whether heterozygous APOB deficiency is ass...

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Detalhes bibliográficos
Principais autores: Peloso, G, Nomura, A, Khera, A, Chaffin, M, Won, H, Ardissino, D, Danesh, J, Schunkert, H, Wilson, J, Samani, N, Erdmann, J, McPherson, R, Watkins, H, Saleheen, D, McCarthy, S, Teslovich, T, Leader, J, Kirchner, H, Marrugat, J, Nohara, A, Kawashiri, M, Tada, H, Dewey, F, Carey, D, Baras, A, Kathiresan, S
Formato: Journal article
Idioma:English
Publicado em: Wolters Kluwer Health 2019

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