Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

Mutations within cytotoxic T lymphocyte (CTL) epitopes impair T cell recognition, but escape mutations arising in flanking regions that alter antigen processing have not been defined in natural human infections. In human histocompatibility leukocyte antigen (HLA)-B57+ HIV-infected persons, immune se...

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Hlavní autoři: Draenert, R, Le Gall, S, Pfafferott, K, Leslie, A, Chetty, P, Brander, C, Holmes, E, Chang, S, Feeney, M, Addo, M, Ruiz, L, Ramduth, D, Jeena, P, Altfeld, M, Thomas, S, Tang, Y, Verrill, C, Dixon, C, Prado, J, Kiepiela, P, Martinez-Picado, J, Walker, B, Goulder, P
Médium: Journal article
Jazyk:English
Vydáno: 2004

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