Structure of the human protein kinase ZAK in complex with vemurafenib.

Structure of the human protein kinase ZAK in complex with vemurafenib.

The mixed lineage kinase ZAK is a key regulator of the MAPK pathway mediating cell survival and inflammatory response. ZAK is targeted by several clinically approved kinase inhibitors, and inhibition of ZAK has been reported to protect fromdoxorubicin-induced cardiomyopathy. On the other hand, unint...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Mathea, S, Abdul Azeez, K, Salah, E, Tallant, C, Wolfreys, F, Konietzny, R, Fischer, R, Lou, H, Brennan, P, Schnapp, G, Pautsch, A, Kessler, B, Turk, B, Knapp, S
التنسيق: Journal article
اللغة:English
منشور في: American Chemical Society 2016

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