Structure of the human protein kinase ZAK in complex with vemurafenib.

Structure of the human protein kinase ZAK in complex with vemurafenib.

The mixed lineage kinase ZAK is a key regulator of the MAPK pathway mediating cell survival and inflammatory response. ZAK is targeted by several clinically approved kinase inhibitors, and inhibition of ZAK has been reported to protect fromdoxorubicin-induced cardiomyopathy. On the other hand, unint...

書誌詳細
主要な著者:	Mathea, S, Abdul Azeez, K, Salah, E, Tallant, C, Wolfreys, F, Konietzny, R, Fischer, R, Lou, H, Brennan, P, Schnapp, G, Pautsch, A, Kessler, B, Turk, B, Knapp, S
フォーマット:	Journal article
言語:	English
出版事項:	American Chemical Society 2016

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