Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.

Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.

BACKGROUND: Aldosterone is an important cardiovascular hormone; 15% of hypertensive subjects have alteration in aldosterone regulation, defined by a raised ratio of aldosterone to renin (ARR). Studies of the aldosterone synthase gene (CYP11B2) have focused on a single nucleotide polymorphism in the...

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Những tác giả chính: Freel, E, Ingram, M, Friel, E, Fraser, R, Brown, M, Samani, N, Caulfield, M, Munroe, P, Farrall, M, Webster, J, Clayton, D, Dominiczak, A, Davies, E, Connell, J
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2007

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