Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses

Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses

The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic of fatal outcomes with coronavirus disease 2019 (COVID-19) is tha...

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Bibliographic Details
Main Authors: McNaughton, AL, Paton, RS, Edmans, M, Youngs, J, Wellens, J, Phalora, P, Fyfe, A, Belij-Rammerstorfer, S, Bolton, JS, Ball, J, Carnell, GW, Dejnirattisai, W, Dold, C, Eyre, DW, Hopkins, P, Howarth, A, Kooblall, K, Klim, H, Leaver, S, Lee, LN, López-Camacho, C, Lumley, SF, Macallan, DC, Mentzer, AJ, Provine, NM, Ratcliff, J, Slon-Compos, J, Skelly, D, Stolle, L, Supasa, P, Temperton, N, Walker, C, Wang, B, Wyncoll, D, Simmonds, P, Lambe, T, Baillie, JK, Semple, MG, Openshaw, PJM, Obolski, U, Turner, M, Carroll, M, Mongkolsapaya, J, Screaton, G, Kennedy, SH, Jarvis, L, Barnes, E, Dunachie, S, Lourenço, J, Matthews, PC, Bicanic, T, Klenerman, P, Gupta, S, Thompson, CP
Other Authors: Oxford Protective T Cell Immunology for COVID-19 (OPTIC) consortium
Format: Journal article
Language:English
Published: American Society for Clinical Investigation 2022
Subjects:
immunology
infectious disease

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