Synthesis of novel enantiopure fluorinated building blocks from acyclic chiral allylsilanes.
[reaction: see text] Homochiral beta-fluorinated gamma,delta-unsaturated carboxylic acids with an allylic fluorinated stereogenic center are available from the corresponding enantiopure allylsilanes. The key step for introduction of the fluorine substituent is an electrophilic fluorodesilylation rea...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
2005
|