Decreased 5-HT-mediated prolactin release in major depression.
The prolactin response to intravenous clomipramine, a 5-HT uptake inhibitor, was significantly attenuated in 12 patients with major depression. In contrast, in a further 12 depressed patients, the PRL responses to thyrotropin-releasing hormone, which acts directly on the pituitary to release PRL, we...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1992
|
| _version_ | 1797101395029000192 |
|---|---|
| author | Anderson, I Ware, C da Roza Davis, J Cowen, P |
| author_facet | Anderson, I Ware, C da Roza Davis, J Cowen, P |
| author_sort | Anderson, I |
| collection | OXFORD |
| description | The prolactin response to intravenous clomipramine, a 5-HT uptake inhibitor, was significantly attenuated in 12 patients with major depression. In contrast, in a further 12 depressed patients, the PRL responses to thyrotropin-releasing hormone, which acts directly on the pituitary to release PRL, were not reduced. These findings suggest that the reduction in 5-HT-mediated PRL release seen in depressed patients is due to an impairment of brain 5-HT function rather than a pituitary abnormality. |
| first_indexed | 2024-03-07T05:51:17Z |
| format | Journal article |
| id | oxford-uuid:e8f8db64-7791-4adc-8f21-dd998c822f23 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:51:17Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:e8f8db64-7791-4adc-8f21-dd998c822f232022-03-27T10:51:03ZDecreased 5-HT-mediated prolactin release in major depression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e8f8db64-7791-4adc-8f21-dd998c822f23EnglishSymplectic Elements at Oxford1992Anderson, IWare, Cda Roza Davis, JCowen, PThe prolactin response to intravenous clomipramine, a 5-HT uptake inhibitor, was significantly attenuated in 12 patients with major depression. In contrast, in a further 12 depressed patients, the PRL responses to thyrotropin-releasing hormone, which acts directly on the pituitary to release PRL, were not reduced. These findings suggest that the reduction in 5-HT-mediated PRL release seen in depressed patients is due to an impairment of brain 5-HT function rather than a pituitary abnormality. |
| spellingShingle | Anderson, I Ware, C da Roza Davis, J Cowen, P Decreased 5-HT-mediated prolactin release in major depression. |
| title | Decreased 5-HT-mediated prolactin release in major depression. |
| title_full | Decreased 5-HT-mediated prolactin release in major depression. |
| title_fullStr | Decreased 5-HT-mediated prolactin release in major depression. |
| title_full_unstemmed | Decreased 5-HT-mediated prolactin release in major depression. |
| title_short | Decreased 5-HT-mediated prolactin release in major depression. |
| title_sort | decreased 5 ht mediated prolactin release in major depression |
| work_keys_str_mv | AT andersoni decreased5htmediatedprolactinreleaseinmajordepression AT warec decreased5htmediatedprolactinreleaseinmajordepression AT darozadavisj decreased5htmediatedprolactinreleaseinmajordepression AT cowenp decreased5htmediatedprolactinreleaseinmajordepression |