Development of a sensitive, scalable method for spatial, cell-type-resolved proteomics of the human brain

Development of a sensitive, scalable method for spatial, cell-type-resolved proteomics of the human brain

While nearly comprehensive proteome coverage can be achieved from bulk tissue or cultured cells, the data usually lacks spatial resolution. As a result, tissue based proteomics averages protein abundance across multiple cell types and/or localizations. With proteomics platforms lacking sensitivity a...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Davis, S, Scott, C, Ansorge, O, Fischer, R
Format:	Journal article
Sprog:	English
Udgivet:	American Chemical Society 2019

Lignende værker

Spatially resolved proteomics of a human brain tumour
af: Davis, S
Udgivet: (2021)

Deep topographic proteomics of a human brain tumour
af: Davis, S, et al.
Udgivet: (2023)

Multiplexed, scalable, and functionality compatible platforms for 3D spatially resolved proteomic profiling
af: Tian, Yuxuan
Udgivet: (2024)

Deep topographic proteomics of a human brain tumour
af: Simon Davis, et al.
Udgivet: (2023-11-01)

Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin
af: Beatrice Dyring-Andersen, et al.
Udgivet: (2020-11-01)

Spatially resolved proteomics via tissue expansion
af: Lu Li, et al.
Udgivet: (2022-11-01)

Region and cell-type resolved quantitative proteomic map of the human heart
af: Sophia Doll, et al.
Udgivet: (2017-11-01)

Brain Cell Type-Specific Nuclear Proteomics Is Imperative to Resolve Neurodegenerative Disease Mechanisms
af: Ruth S. Nelson, et al.
Udgivet: (2022-06-01)

Spatially resolved mapping of proteome turnover dynamics with subcellular precision
af: Feng Yuan, et al.
Udgivet: (2023-11-01)

Spatially-resolved proteomics and transcriptomics: An emerging digital spatial profiling approach for tumor microenvironment
af: Wang Nan, et al.
Udgivet: (2021-01-01)

A region-resolved mucosa proteome of the human stomach
af: Xiaotian Ni, et al.
Udgivet: (2019-01-01)

Dissecting the brain with spatially resolved multi-omics
af: Yijia Fangma, et al.
Udgivet: (2023-07-01)

Unbiased classification of the elderly human brain proteome resolves distinct clinical and pathophysiological subtypes of cognitive impairment
af: Lenora Higginbotham, et al.
Udgivet: (2023-10-01)

A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain
af: Anoushka Joglekar, et al.
Udgivet: (2021-01-01)

Proteomics and transcriptomics of the Betz cell in the human brain
af: Scott, C
Udgivet: (2021)

Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2
af: Hung, Victoria, et al.
Udgivet: (2016)

Multimodal single cell-resolved spatial proteomics reveal pancreatic tumor heterogeneity
af: Yanfen Xu, et al.
Udgivet: (2024-11-01)

Spatially resolved proteomic map shows that extracellular matrix regulates epidermal growth
af: Jun Li, et al.
Udgivet: (2022-07-01)

Spatially resolved proteomics identify biomarkers from endometrial sentinel lymph nodes
af: Renliang Li, et al.
Udgivet: (2021-06-01)

Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain
af: Sruti Rayaprolu, et al.
Udgivet: (2022-05-01)

Scalable Subcellular Resolution Mapping of the Human Brain
af: Guan, Webster
Udgivet: (2023)

New chemical biopsy tool for spatially resolved profiling of human brain tissue in vivo
af: Joanna Bogusiewicz, et al.
Udgivet: (2021-09-01)

Genetically encoded photocatalytic protein labeling enables spatially-resolved profiling of intracellular proteome
af: Fu Zheng, et al.
Udgivet: (2023-05-01)

83 Spatially resolved transcriptomic and proteomic investigation of breast cancer and its immune microenvironment
af: Stephen Williams, et al.
Udgivet: (2021-11-01)

Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding
af: Rongbo Shen, et al.
Udgivet: (2022-12-01)

High-sensitive spatially resolved T cell receptor sequencing with SPTCR-seq
af: Jasim Kada Benotmane, et al.
Udgivet: (2023-11-01)

Spatially and spectrally resolved multicore optical fiber sensor with polarization sensitivity
af: Y. Hou, et al.
Udgivet: (2022-06-01)

Spatial region-resolved proteome map reveals mechanism of COVID-19-associated heart injury
af: Ling Leng, et al.
Udgivet: (2022-06-01)

Spatially resolved analysis of Pseudomonas aeruginosa biofilm proteomes measured by laser ablation sample transfer.
af: Aruni Chathurya Pulukkody, et al.
Udgivet: (2021-01-01)

The proteome of human brain microdialysate
af: Feldmann Robert E, et al.
Udgivet: (2003-12-01)

A proteomic network approach across the ALS‐FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain
af: Mfon E Umoh, et al.
Udgivet: (2017-11-01)

SMASH: Scalable Method for Analyzing Spatial Heterogeneity of genes in spatial transcriptomics data.
af: Souvik Seal, et al.
Udgivet: (2023-10-01)

Publisher Correction: Genetically encoded photocatalytic protein labeling enables spatially-resolved profiling of intracellular proteome
af: Fu Zheng, et al.
Udgivet: (2023-08-01)

Spatially and temporally resolved metabolome of the human oral cavity
af: Alessio Ciurli, et al.
Udgivet: (2024-02-01)

Using Temporally and Spatially Resolved Measurements to Improve the Sensitivity of Fluorescence-Based Immunoassays
af: Ran Kremer, et al.
Udgivet: (2024-04-01)

Representative proteomes: a stable, scalable and unbiased proteome set for sequence analysis and functional annotation.
af: Chuming Chen, et al.
Udgivet: (2011-04-01)

Capillary Electrophoresis Mass Spectrometry for Scalable Single-Cell Proteomics
af: Bowen Shen, et al.
Udgivet: (2022-04-01)

A highly scalable peptide-based assay system for proteomics.
af: Igor A Kozlov, et al.
Udgivet: (2012-01-01)

Scalable Delay-Sensitive Polling of Sensors
af: Hootan Rashtian, et al.
Udgivet: (2020-01-01)

Scalable mapping of myelin and neuron density in the human brain with micrometer resolution
af: Shuaibin Chang, et al.
Udgivet: (2022-01-01)