S-adenosylmethionine in rat liver cirrhosis

An experimental model of cirrhosis in rats, by means carbon tetrachloride (CCl4) and ethanol during two months, was used to assess the effectiveness of S-adenosylmethionine. Histological studies of the liver and examination of different biochemical parameters of hepatic function were also employed....

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Cutrin, C, Menino, M, Carballo, C, Parafita, M, Perez-Becerra, E, Barrio, E
التنسيق: Journal article
اللغة:English
منشور في: 1993
الوصف
الملخص:An experimental model of cirrhosis in rats, by means carbon tetrachloride (CCl4) and ethanol during two months, was used to assess the effectiveness of S-adenosylmethionine. Histological studies of the liver and examination of different biochemical parameters of hepatic function were also employed. Bilirubin and lactic acid levels decreased significantly in the group treated with S-adenosylmethionine in comparison with the CCl4 + ethanol group. Histologic liver studies showed a significant improvement relative to fatty liver, Mallory bodies, infiltrate polymorphonuclear and perivenular fibrosis. A slight decrease in cirrhosis was observed in the animals treated with S- adenosylmethionine.