S-adenosylmethionine in rat liver cirrhosis
An experimental model of cirrhosis in rats, by means carbon tetrachloride (CCl4) and ethanol during two months, was used to assess the effectiveness of S-adenosylmethionine. Histological studies of the liver and examination of different biochemical parameters of hepatic function were also employed....
| Autors principals: | , , , , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
1993
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| Sumari: | An experimental model of cirrhosis in rats, by means carbon tetrachloride (CCl4) and ethanol during two months, was used to assess the effectiveness of S-adenosylmethionine. Histological studies of the liver and examination of different biochemical parameters of hepatic function were also employed. Bilirubin and lactic acid levels decreased significantly in the group treated with S-adenosylmethionine in comparison with the CCl4 + ethanol group. Histologic liver studies showed a significant improvement relative to fatty liver, Mallory bodies, infiltrate polymorphonuclear and perivenular fibrosis. A slight decrease in cirrhosis was observed in the animals treated with S- adenosylmethionine. |
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