Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

Toon andere (1) versies

The TREK subfamily of two-pore domain (K2P) K+ channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the “up” and “down” conformations. However, recent studies have resulted in contradicto...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	McClenaghan, C, Schewe, M, Aryal, P, Carpenter, E, Baukrowitz, T, Tucker, S
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	Rockefeller University Press 2016

Gelijkaardige items

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.
door: McClenaghan, C, et al.
Gepubliceerd in: (2016)

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.
door: Aryal, P, et al.
Gepubliceerd in: (2017)

Investigations into the structure, function and pharmacology of TREK K2P potassium channels
door: McClenaghan, C
Gepubliceerd in: (2015)

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate
door: Proks, P, et al.
Gepubliceerd in: (2021)

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
door: Dong, Y, et al.
Gepubliceerd in: (2015)

The effects of stretch activation on ionic selectivity of the TREK-2 K2P K(+) channel
door: Nematian-Ardestani, E, et al.
Gepubliceerd in: (2017)

Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels
door: Berke Türkaydin, et al.
Gepubliceerd in: (2024-05-01)

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
door: Rödström, KEJ, et al.
Gepubliceerd in: (2024)

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
door: Karin E. J. Rödström, et al.
Gepubliceerd in: (2024-05-01)

Effects of ionic strength on gating and permeation of TREK-2 K2P channels
door: Conrad, LJ, et al.
Gepubliceerd in: (2021)

Effects of ionic strength on gating and permeation of TREK-2 K2P channels.
door: Linus J Conrad, et al.
Gepubliceerd in: (2021-01-01)

Transition between conformational states of the TREK-1 K2P channel promoted by interaction with PIP2
door: Panasawatwong, A, et al.
Gepubliceerd in: (2022)

A novel mechanism of voltage sensing and gating in K2P potassium channels
door: Schewe, M, et al.
Gepubliceerd in: (2014)

A Novel Mechanism of Voltage Sensing and Gating in K2P Potassium Channels
door: Schewe, M, et al.
Gepubliceerd in: (2014)

A novel mechanism of voltage sensing and gating in K2P potassium channels
door: Rapedius, M, et al.
Gepubliceerd in: (2014)

Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2
door: Ben Sorum, et al.
Gepubliceerd in: (2024-04-01)

Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel
door: Nematian-Ardestani, E, et al.
Gepubliceerd in: (2019)

Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters
door: Marcos Matamoros, et al.
Gepubliceerd in: (2023-01-01)

Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia
door: Niels Decher, et al.
Gepubliceerd in: (2017-02-01)

A non-canonical voltage-sensing mechanism controls gating in K2P K(+) channels
door: Schewe, M, et al.
Gepubliceerd in: (2016)

POLYMODALITY OF SECONDARY KAOLINITE DISTRIBUTION IN OPEN SANDY RESERVOIR SYSTEMS
door: Igor A. Melnik
Gepubliceerd in: (2023-08-01)

Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines
door: Rían W. Manville, et al.
Gepubliceerd in: (2024-08-01)

Characterization of temperature-sensitive leak K+ currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats
door: Viacheslav Viatchenko-Karpinski, et al.
Gepubliceerd in: (2018-07-01)

K2P and Kir K+ Channels in Physiological Bilayers
door: Schmidt, MR, et al.
Gepubliceerd in: (2013)

A new polymodal gating model of the proton-activated chloride channel.
door: Piao Zhao, et al.
Gepubliceerd in: (2023-09-01)

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.
door: Rapedius, M, et al.
Gepubliceerd in: (2012)

Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine and CEN-092
door: Yvonne Walsh, et al.
Gepubliceerd in: (2021-07-01)

Elevated expression of TREK-TRAAK K2P channels in the retina of adult rd1 mice
door: Xiao-Tong Zhang, et al.
Gepubliceerd in: (2019-06-01)

Are TREK Channels Temperature Sensors?
door: Lola Rueda-Ruzafa, et al.
Gepubliceerd in: (2021-10-01)

K2P2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury
door: Tatiana Zyrianova, et al.
Gepubliceerd in: (2020-12-01)

The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels
door: Rinné, S, et al.
Gepubliceerd in: (2019)

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2
door: Lea C. Neelsen, et al.
Gepubliceerd in: (2024-08-01)

Conformational rearrangements during PIP2 gating in Kir channels
door: Rapedius, M, et al.
Gepubliceerd in: (2007)

TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors
door: Robin Jonas, et al.
Gepubliceerd in: (2020-02-01)

The biophysical and structural mechanisms underlying mechanosensitivity of the TREK-2 potassium channel
door: Jarerattanachat, V
Gepubliceerd in: (2018)

2-Aminoethoxydiphenyl borate activates the human mechano-gated KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK) and KCNK 10 (TREK-2).
door: Leopoldo Raul Beltran, et al.
Gepubliceerd in: (2013-05-01)

Evolution of a polymodal sensory response network
door: Sternberg Paul W, et al.
Gepubliceerd in: (2008-12-01)

The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels
door: Kevin P. Cunningham, et al.
Gepubliceerd in: (2021-06-01)

The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels
door: Susanne Rinné, et al.
Gepubliceerd in: (2019-02-01)

Structural and Mechanistic Insights into Gating of K2P Channels
door: Rapedius, M, et al.
Gepubliceerd in: (2012)