Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

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The TREK subfamily of two-pore domain (K2P) K+ channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the “up” and “down” conformations. However, recent studies have resulted in contradicto...

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Библиографические подробности
Главные авторы:	McClenaghan, C, Schewe, M, Aryal, P, Carpenter, E, Baukrowitz, T, Tucker, S
Формат:	Journal article
Язык:	English
Опубликовано:	Rockefeller University Press 2016

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