Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.

Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.

Identification of the signaling pathways that regulate cyclic nucleotide microdomains is essential to our understanding of cardiac physiology and pathophysiology. Although there is growing evidence that the plasma membrane Ca(2+)/calmodulin-dependent ATPase 4 (PMCA4) is a regulator of neuronal nitri...

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Bibliographic Details
Main Authors: Mohamed, T, Oceandy, D, Zi, M, Prehar, S, Alatwi, N, Wang, Y, Shaheen, M, Abou-Leisa, R, Schelcher, C, Hegab, Z, Baudoin, F, Emerson, M, Mamas, M, Di Benedetto, G, Zaccolo, M, Lei, M, Cartwright, E, Neyses, L
Format: Journal article
Language:English
Published: 2011

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