Choroideremia: molecular mechanisms and development of AAV gene therapy

<p><strong>Introduction:</strong> Choroideremia is an X-linked inherited retinal degeneration that causes blindness in afflicted males by middle age. The causative gene, CHM, plays a key role in intracellular trafficking pathways, and its disruption impairs cell homeostasis.</p&...

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Bibliographic Details
Main Authors: Patrício, M, Barnard, A, Xue, K, MacLaren, R
Format: Journal article
Language:English
Published: Taylor and Francis 2018