Strategy for designing selective α-L-rhamnosidase inhibitors: Synthesis and biological evaluation of DMDP cyclic isothioureas
This study shows that the cyclization of L-DMDP thioureas to bicyclic L-DMDP isothioureas improved a-Lrhamnosidase inhibition which was further enhanced by increasing the length of the alkyl chain. The addition of a long alkyl chain, such as decyl or dodecyl, to the nitrogen led to the production of...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2016
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