Model complexes of cobalt-substituted matrix metalloproteinases: tools for inhibitor design.
The tetrahedral cobalt(II) complex [(Tp(Ph,Me))CoCl] (Tp(Ph,Me) = hydrotris(3,5-phenylmethylpyrazolyl)borate) was combined with several hydroxypyridinone, hydroxypyridinethione, pyrone, and thiopyrone ligands to form the corresponding [(Tp(Ph,Me))Co(L)] complexes. X-ray crystal structures of these c...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797101532780429312 |
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| author | Jacobsen, F Breece, R Myers, W Tierney, D Cohen, S |
| author_facet | Jacobsen, F Breece, R Myers, W Tierney, D Cohen, S |
| author_sort | Jacobsen, F |
| collection | OXFORD |
| description | The tetrahedral cobalt(II) complex [(Tp(Ph,Me))CoCl] (Tp(Ph,Me) = hydrotris(3,5-phenylmethylpyrazolyl)borate) was combined with several hydroxypyridinone, hydroxypyridinethione, pyrone, and thiopyrone ligands to form the corresponding [(Tp(Ph,Me))Co(L)] complexes. X-ray crystal structures of these complexes were obtained to determine the mode of binding for each ligand L. The structures show that the [(Tp(Ph,Me))Co(L)] complexes are pentacoordinate complexes, with a general tendency toward square pyramidal geometry. The electronic, EPR, and paramagnetic NMR spectroscopy of the [(Tp(Ph,Me))Co(L)] complexes have been examined. The frozen-solution EPR spectra are indicative of pentacoordination in frozen solution, while the NMR indicates some dynamics in ligand binding. The findings presented here suggest that [(Tp(Ph,Me))Co(L)] complexes can be used as spectroscopic references for investigating the mode of inhibitor binding in metalloproteinases of medicinal interest. Potential limitations when using cobalt(II) model complexes are also discussed. |
| first_indexed | 2024-03-07T05:53:10Z |
| format | Journal article |
| id | oxford-uuid:e99afa96-0c3b-4219-94b6-3929b5279bf7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:53:10Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:e99afa96-0c3b-4219-94b6-3929b5279bf72022-03-27T10:55:29ZModel complexes of cobalt-substituted matrix metalloproteinases: tools for inhibitor design.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e99afa96-0c3b-4219-94b6-3929b5279bf7EnglishSymplectic Elements at Oxford2006Jacobsen, FBreece, RMyers, WTierney, DCohen, SThe tetrahedral cobalt(II) complex [(Tp(Ph,Me))CoCl] (Tp(Ph,Me) = hydrotris(3,5-phenylmethylpyrazolyl)borate) was combined with several hydroxypyridinone, hydroxypyridinethione, pyrone, and thiopyrone ligands to form the corresponding [(Tp(Ph,Me))Co(L)] complexes. X-ray crystal structures of these complexes were obtained to determine the mode of binding for each ligand L. The structures show that the [(Tp(Ph,Me))Co(L)] complexes are pentacoordinate complexes, with a general tendency toward square pyramidal geometry. The electronic, EPR, and paramagnetic NMR spectroscopy of the [(Tp(Ph,Me))Co(L)] complexes have been examined. The frozen-solution EPR spectra are indicative of pentacoordination in frozen solution, while the NMR indicates some dynamics in ligand binding. The findings presented here suggest that [(Tp(Ph,Me))Co(L)] complexes can be used as spectroscopic references for investigating the mode of inhibitor binding in metalloproteinases of medicinal interest. Potential limitations when using cobalt(II) model complexes are also discussed. |
| spellingShingle | Jacobsen, F Breece, R Myers, W Tierney, D Cohen, S Model complexes of cobalt-substituted matrix metalloproteinases: tools for inhibitor design. |
| title | Model complexes of cobalt-substituted matrix metalloproteinases: tools for inhibitor design. |
| title_full | Model complexes of cobalt-substituted matrix metalloproteinases: tools for inhibitor design. |
| title_fullStr | Model complexes of cobalt-substituted matrix metalloproteinases: tools for inhibitor design. |
| title_full_unstemmed | Model complexes of cobalt-substituted matrix metalloproteinases: tools for inhibitor design. |
| title_short | Model complexes of cobalt-substituted matrix metalloproteinases: tools for inhibitor design. |
| title_sort | model complexes of cobalt substituted matrix metalloproteinases tools for inhibitor design |
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