The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses

The human monoclonal antibody C10 exhibits extraordinary cross-reactivity, potently neutralizing Zika virus (ZIKV) and the four serotypes of dengue virus (DENV1–DENV4). Here we describe a comparative structure-function analysis of C10 bound to the envelope (E) protein dimers of the five viruses it n...

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Xehetasun bibliografikoak
Egile Nagusiak: Sharma, A, Zhang, X, Dejnirattisai, W, Dai, X, Gong, D, Wongwiwat, W, Duquerroy, S, Rouvinski, A, Vaney, M-C, Guardado-Calvo, P, Haouz, A, England, P, Sun, R, Zhou, ZH, Mongkolsapaya, J, Screaton, G, Rey, FA
Formatua: Journal article
Hizkuntza:English
Argitaratua: Cell Press 2021