Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.

Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.

Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused, in most cases, by the complete absence of the 427 kDa cytoskeletal protein, dystrophin. There is no effective treatment, and affected individuals die from respiratory failure and cardiomyopathy by age 30. Here, we investigate...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Crisp, A, Yin, H, Goyenvalle, A, Betts, C, Moulton, H, Seow, Y, Babbs, A, Merritt, T, Saleh, A, Gait, M, Stuckey, D, Clarke, K, Davies, K, Wood, M
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2011

Παρόμοια τεκμήρια

Prevention of dystrophic pathology in severely affected dystrophin/utrophin-deficient mice by morpholino-oligomer-mediated exon-skipping.
ανά: Goyenvalle, A, κ.ά.
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Upgrading U7snRNA To Complete Efficient Rescue of Dystrophin by Exon-Skipping in DMD Patients
ανά: Goyenvalle, A, κ.ά.
Έκδοση: (2009)

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO
ανά: Yin, H, κ.ά.
Έκδοση: (2010)

Rescu of severely affected dystrophin/utrophin deficient mice by morpholino-oligomer mediated exon skipping
ανά: Goyenvalle, A, κ.ά.
Έκδοση: (2010)

Lipolysis and cyclic AMP response to isoproterenol in diaphragms from control and dystrophic mice.
ανά: N A Abumrad, κ.ά.
Έκδοση: (1980-02-01)

NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice
ανά: James Anthony Loehr, κ.ά.
Έκδοση: (2018-01-01)

Correction: NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice
ανά: James Anthony Loehr, κ.ά.
Έκδοση: (2022-10-01)

Dystrophic phenotype improvement in the diaphragm muscle of mdx mice by diacerhein.
ανά: Rafael Dias Mâncio, κ.ά.
Έκδοση: (2017-01-01)

Spatial and age-related changes in the microstructure of dystrophic and healthy diaphragms.
ανά: Catherine C Henry, κ.ά.
Έκδοση: (2017-01-01)

Proteome Profiling of the Dystrophic <i>mdx</i> Mice Diaphragm
ανά: Olga Mucha, κ.ά.
Έκδοση: (2023-11-01)

Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping
ανά: Goyenvalle, A, κ.ά.
Έκδοση: (2012)

Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping.
ανά: Goyenvalle, A, κ.ά.
Έκδοση: (2012)

The force-temperature relationship in healthy and dystrophic mouse diaphragm; implications for translational study design.
ανά: Jason D Murray, κ.ά.
Έκδοση: (2012-11-01)

AAV-U7snRNA mediated multi exon-skipping for Duchenne muscular dystrophy
ανά: Goyenvalle, A, κ.ά.
Έκδοση: (2010)

Proteomic Identification of Markers of Membrane Repair, Regeneration and Fibrosis in the Aged and Dystrophic Diaphragm
ανά: Stephen Gargan, κ.ά.
Έκδοση: (2022-10-01)

Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice.
ανά: Yin, H, κ.ά.
Έκδοση: (2011)

NOVEL CELL PENETRATING PEPTIDES FOR SKELETAL AND CARDIAC MUSCLE DELIVERY OF PMO ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY
ανά: Hammond, S, κ.ά.
Έκδοση: (2011)

Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice
ανά: Yin, H, κ.ά.
Έκδοση: (2011)

Profile of circadianly regulated metabolic genes in dystrophic heart
ανά: Betts, C, κ.ά.
Έκδοση: (2018)

AAV-U7snRNA mediated multi exon-skipping for Duchenne muscular dystrophy
ανά: Goyenvalle, A, κ.ά.
Έκδοση: (2011)

AAV genome loss from dystrophic mouse muscles during AAV-U7 snRNA-mediated exon-skipping therapy
ανά: Le Hir, M, κ.ά.
Έκδοση: (2013)

Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study.
ανά: Zhang, W, κ.ά.
Έκδοση: (2008)

Increased mitochondrial uncoupling protein 3 is associated with the cardiomyopathy in the dystrophic mouse heart
ανά: Zhang, W, κ.ά.
Έκδοση: (2006)

The extracellular matrix of dystrophic mouse diaphragm accounts for the majority of its passive stiffness and is resistant to collagenase digestion
ανά: Ross P. Wohlgemuth, κ.ά.
Έκδοση: (2023-06-01)

Progressive Dystrophic Pathology in Diaphragm and Impairment of Cardiac Function in FKRP P448L Mutant Mice.
ανά: Anthony Blaeser, κ.ά.
Έκδοση: (2016-01-01)

Enhanced exon-skipping induced by U7 snRNA carrying a splicing silencer sequence: Promising tool for DMD therapy.
ανά: Goyenvalle, A, κ.ά.
Έκδοση: (2009)

In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy.
ανά: Wang, Q, κ.ά.
Έκδοση: (2010)

Up-regulation of utrophin alleviates the dystrophic phenotype in the mdx mouse heart
ανά: Sang, E, κ.ά.
Έκδοση: (2000)

The Cellular Processing Capacity Limits the Amounts of Chimeric U7 snRNA Available for Antisense Delivery.
ανά: Eckenfelder, A, κ.ά.
Έκδοση: (2012)

Engineering multiple U7snRNA constructs to induce single and multiexon-skipping for Duchenne muscular dystrophy
ανά: Goyenvalle, A, κ.ά.
Έκδοση: (2012)

Engineering multiple U7snRNA constructs to induce single and multiexon-skipping for Duchenne muscular dystrophy.
ανά: Goyenvalle, A, κ.ά.
Έκδοση: (2012)

A case of recessive dystrophic epidermolysis bullosa
ανά: K Kocabay, κ.ά.
Έκδοση: (1988-07-01)

Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse.
ανά: Yin, H, κ.ά.
Έκδοση: (2010)

Wearables alone will not eliminate failure to rescue
ανά: Jeanine P. Wiener-Kronish, κ.ά.
Έκδοση: (2022-06-01)

Increased susceptibility of the dystrophic mdx mouse heart to ischemic and hypoxic injuries
ανά: Zhang, W, κ.ά.
Έκδοση: (2005)

Murine cardiosphere-derived cells are impaired by age but not by cardiac dystrophic dysfunction.
ανά: Hsiao, L, κ.ά.
Έκδοση: (2014)

Immortalized canine dystrophic myoblast cell lines for development of peptide-conjugated splice-switching oligonucleotides
ανά: Tone, Y, κ.ά.
Έκδοση: (2021)

Ventilator-Induced Diaphragm Dysfunction (Review)
ανά: M. A. Babaev, κ.ά.
Έκδοση: (2018-07-01)

Tricyclo-DNA: A promising chemistry for the synthesis of antisense molecules for splice-switching approaches in DMD
ανά: Goyenvalle, A, κ.ά.
Έκδοση: (2012)

Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse.
ανά: Joshua T Selsby, κ.ά.
Έκδοση: (2012-01-01)