Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

<p><strong>Objectives:</strong>&nbsp;Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD)&mdash;a widely used mouse model of prediabet...

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Bibliographic Details
Main Authors: Kellard, J, Rorsman, N, Hill, T, van der Bunt, M, Armour, S, Rorsman, P, Knudsen, J, Briant, L
Format: Journal article
Language:English
Published: Elsevier 2020