Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations.

Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations.

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Children with Down's syndrome (DS) have an increased risk of developing acute lymphoblastic leukemia (ALL) and have a low frequency of established genetic aberrations. We aimed to determine which genetic abnormalities are involved in DS ALL. We studied the frequency and prognostic value of dele...

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Bibliographic Details
Main Authors: Buitenkamp, T, Pieters, R, Gallimore, N, van der Veer, A, Meijerink, J, Beverloo, H, Zimmermann, M, de Haas, V, Richards, S, Vora, A, Mitchell, C, Russell, L, Schwab, C, Harrison, C, Moorman, A, van den Heuvel-Eibrink, MM, den Boer, M, Zwaan, C
Format: Journal article
Language:English
Published: 2012

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