Principles of reconstructing the subclonal architecture of cancers

Principles of reconstructing the subclonal architecture of cancers

Most cancers evolve from a single founder cell through a series of clonal expansions that are driven by somatic mutations. These clonal expansions can lead to several coexisting subclones sharing subsets of mutations. Analysis of massively parallel sequencing data can infer a tumor's subclonal...

書誌詳細
主要な著者:	Dentro, S, Wedge, D, Van Loo, P
フォーマット:	Journal article
言語:	English
出版事項:	Cold Spring Harbor Laboratory Press 2017

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