Principles of reconstructing the subclonal architecture of cancers

Principles of reconstructing the subclonal architecture of cancers

Most cancers evolve from a single founder cell through a series of clonal expansions that are driven by somatic mutations. These clonal expansions can lead to several coexisting subclones sharing subsets of mutations. Analysis of massively parallel sequencing data can infer a tumor's subclonal...

Полное описание

Библиографические подробности
Главные авторы:	Dentro, S, Wedge, D, Van Loo, P
Формат:	Journal article
Язык:	English
Опубликовано:	Cold Spring Harbor Laboratory Press 2017

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