Cold induces shifts of voltage dependence in mutant SCN4A, causing hypokalemic periodic paralysis.
BACKGROUND: The authors reported a mutation, P1158S, of the human skeletal muscle sodium channel gene (SCN4A) in a family with cold-induced hypokalemic periodic paralysis (hypoKPP) and myotonia. OBJECTIVE: To identify mechanisms of temperature dependency in this channelopathy. METHODS: Using the amp...
| Main Authors: | , , , , , , , |
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| Format: | Conference item |
| Published: |
2003
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