CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2

Aurora-A is an essential cell-cycle kinase with critical roles in mitotic entry and spindle dynamics. These functions require binding partners such as CEP192 and TPX2, which modulate both kinase activity and localisation of Aurora-A. Here we investigate the structure and role of the centrosomal Auro...

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Bibliographic Details
Main Authors: Holder, J, Miles, JA, Batchelor, M, Popple, H, Walko, M, Yeung, W, Kannan, N, Wilson, AJ, Bayliss, R, Gergely, F
Format: Journal article
Language:English
Published: EMBO Press 2024