Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.

Lipid transfer proteins, such as molecules of the saposin family, facilitate extraction of lipids from biological membranes for their loading onto CD1d molecules. Although it has been shown that prosaposin-deficient mice fail to positively select invariant natural killer T (iNKT) cells, it remains u...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Salio, M, Ghadbane, H, Dushek, O, Shepherd, D, Cypen, J, Gileadi, U, Aichinger, M, Napolitani, G, Qi, X, Van Der Merwe, P, Wojno, J, Veerapen, N, Cox, L, Besra, G, Yuan, W, Cresswell, P, Cerundolo, V
Format: Journal article
Sprache:English
Veröffentlicht: 2013

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