Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice.

Using hepatitis B virus (HBV) transgenic mice as recipients of virus-specific cytotoxic T lymphocytes (CTLs), we recently showed that polymorphonuclear neutrophils (PMNs) and the matrix-degrading metalloproteinases (MMPs) they produce are necessary for the intrahepatic recruitment of antigen nonspec...

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Hlavní autoři: Sitia, G, Iannacone, M, Müller, S, Bianchi, M, Guidotti, L
Médium: Journal article
Jazyk:English
Vydáno: 2007