Discontinuation of fucose therapy in LADII causes rapid loss of selectin ligands and rise of leukocyte counts.

Leukocyte adhesion deficiency type II (LADII) is a rare inherited disorder of fucose metabolism. Patients with LADII lack fucosylated glycoconjugates, including the carbohydrate ligands of the selectins, leading to an immunodeficiency caused by the lack of selectin-mediated leukocyte-endothelial int...

Полное описание

Библиографические подробности
Главные авторы: Lühn, K, Marquardt, T, Harms, E, Vestweber, D
Формат: Journal article
Язык:English
Опубликовано: 2001