Genetic segregation analysis of familial mitral valve prolapse shows no linkage to fibrillar collagen genes.
Three pedigrees were identified in which mitral valve prolapse seemed to be inherited as a mendelian autosomal dominant trait. The segregation of the genes encoding the major fibrillar collagens present in valve tissue, collagens I and III, was analysed by use of restriction enzyme site variants as...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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