FOXFIRE protocol: an open-label, randomised, phase III trial of 5-fluorouracil, oxaliplatin and folinic acid (OxMdG) with or without interventional Selective Internal Radiation Therapy (SIRT) as first-line treatment for patients with unresectable liver-only or liver-dominant metastatic colorectal cancer

BACKGROUND: Colorectal cancer (CRC) is the second most common malignancy in Europe and a leading cause of cancer-related death. Almost 50% of patients with CRC develop liver metastases, which heralds a poor prognosis unless metastases can be downsized to surgical resection or ablation. The FOXFIRE t...

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Bibliographic Details
Main Authors: Dutton, S, Kenealy, N, Love, S, Wasan, H, Sharma, R, on behalf of the FOXFIRE Protocol Development Group and the NCRI Colorectal Clinical Study Group
Format: Journal article
Language:English
Published: BioMed Central 2014