Proteomic and microarray analyses of the Dictyostelium Zak1-GSK-3 signaling pathway reveal a role in early development.

GskA, the Dictyostelium GSK-3 orthologue, is modified and activated by the dual-specificity tyrosine kinase Zak1, and the two kinases form part of a signaling pathway that responds to extracellular cyclic AMP. We identify potential cellular effectors for the two kinases by analyzing the correspondin...

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Bibliographic Details
Main Authors: Strmecki, L, Bloomfield, G, Araki, T, Dalton, E, Skelton, J, Schilde, C, Harwood, A, Williams, J, Ivens, A, Pears, C
Format: Journal article
Language:English
Published: 2007