Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.

Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.

The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Thimme, R, Appay, V, Koschella, M, Panther, E, Roth, E, Hislop, A, Rickinson, AB, Rowland-Jones, S, Blum, H, Pircher, H
Natura:	Journal article
Lingua:	English
Pubblicazione:	2005

Documenti analoghi

N-cadherin protects oral cancer cells from NK cell killing in the circulation by inducing NK cell functional exhaustion via the KLRG1 receptor
di: Qin Xu, et al.
Pubblicazione: (2022-09-01)

In Vivo Zymosan Treatment Induces IL15-Secreting Macrophages and KLRG1-Expressing NK Cells in Mice
di: Hyun Jung Park, et al.
Pubblicazione: (2023-07-01)

Increased expression of TIGIT and KLRG1 correlates with impaired CD56bright NK cell immunity in HPV16-related cervical intraepithelial neoplasia
di: You Nie, et al.
Pubblicazione: (2022-04-01)

Proteome-wide analysis of CD8+ T cell responses to EBV reveals differences between primary and persistent infection.
di: Calum Forrest, et al.
Pubblicazione: (2018-09-01)

Expansion of CD57+KLRG1+ T cells is associated with reduced vaccine responses in CMV+ young adults
di: Bowyer, G, et al.
Pubblicazione: (2020)

The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular staining.
di: Appay, V, et al.
Pubblicazione: (2002)

Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+ KLRG1− CD4+ T cells
di: Bull, N, et al.
Pubblicazione: (2018)

KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B.
di: Li Wang, et al.
Pubblicazione: (2024-01-01)

The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells
di: Samantha M. Borys, et al.
Pubblicazione: (2022-04-01)

CD154 blockade alters innate immune cell recruitment and programs alloreactive CD8+ T cells into KLRG-1(high) short-lived effector T cells.
di: Ivana R Ferrer, et al.
Pubblicazione: (2012-01-01)

572 PYX-102, an anti-KLRG1 antibody, enhances cytotoxic activity of CD8-T-cells from PBMC and human tumor samples by blocking the interaction between KLRG1 and cadherins
di: Ronald Herbst, et al.
Pubblicazione: (2023-11-01)

PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127+ and KLRG1+ CD8 T cells
di: Zhenzhen Hui, et al.
Pubblicazione: (2023-05-01)

KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response
di: Charles G Drake, et al.
Pubblicazione: (2023-09-01)

Lessons from the study of T-cell differentiation in persistent human virus infection.
di: Appay, V, et al.
Pubblicazione: (2004)

Dysregulation of peripheral and intratumoral KLRG1+ CD8+ T cells is associated with immune evasion in patients with non-small-cell lung cancer
di: Juan Zeng, et al.
Pubblicazione: (2024-07-01)

KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease
di: Hugo Bottois, et al.
Pubblicazione: (2020-05-01)

Virus-specific CD4+ T cell responses in chronic HCV infection in blood and liver identified by antigen-specific upregulation of CD154.
di: Mueller, M, et al.
Pubblicazione: (2010)

Harnessing the Induction of CD8+ T-Cell Responses Through Metabolic Regulation by Pathogen-Recognition-Receptor Triggering in Antigen Presenting Cells
di: Francesco Nicoli, et al.
Pubblicazione: (2018-10-01)

Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.
di: Amyes, E, et al.
Pubblicazione: (2003)

Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation
di: Yumeng Sun, et al.
Pubblicazione: (2025-02-01)

Expression of KLRG1 and CD127 defines distinct CD8+ subsets that differentially impact patient outcome in follicular lymphoma
di: Hyo Jin Kim, et al.
Pubblicazione: (2021-07-01)

Tumor-associated changes in intestinal epithelial cells cause local accumulation of KLRG1(+) GATA3(+) regulatory T cells in mice
di: Meinicke, H, et al.
Pubblicazione: (2017)

Persistent NK cell deficiency associated with pulmonary cryptococcosis
di: Martin Martinot, et al.
Pubblicazione: (2025-01-01)

Clonal expansions in acute EBV infection are detectable in the CD8 and not the CD4 subset and persist with a variable CD45 phenotype.
di: Maini, M, et al.
Pubblicazione: (2000)

Contribution of antigenic exposure to the persistence of HIV-infected CD4 T cells in vivo
di: F. Simonetti, et al.
Pubblicazione: (2019-12-01)

Adaptive memory of human NK-like CD8+ T-cells to ageing, and viral and tumor antigens
di: MARIA LUISA PITA-LOPEZ, et al.
Pubblicazione: (2016-12-01)

The role of KLRG1: a novel biomarker and new therapeutic target
di: Yakun Zhang, et al.
Pubblicazione: (2024-06-01)

Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy
di: Xiaodong Yang, et al.
Pubblicazione: (2021-06-01)

NK cells and solid tumors: therapeutic potential and persisting obstacles
di: Le Tong, et al.
Pubblicazione: (2022-11-01)

OP 4.1 Viral persistence and NK cells
di: Michaela Müller-Trutwin
Pubblicazione: (2022-12-01)

Flow cytometric visualisation of cytokine production by CD3-CD56+ NK cells and CD3+CD56+ NK-T cells in whole blood.
di: Mendes, R, et al.
Pubblicazione: (2000)

Elevated CD54 expression renders CD4+ T cells susceptible to NK cell-mediated killing.
di: Chen, X, et al.
Pubblicazione: (2019)

On T Cell Memory: Arguments for Antigen Dependence
di: Kündig, T, et al.
Pubblicazione: (1996)

On T cell memory: arguments for antigen dependence.
di: Kündig, T, et al.
Pubblicazione: (1996)

PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE
di: V. A. Mikhailova, et al.
Pubblicazione: (2017-01-01)

Reciprocal recognition of an HLA-Cw4-restricted HIV-1 gp120 epitope by CD8+ T cells and NK cells.
di: Thananchai, H, et al.
Pubblicazione: (2009)

Development of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines
di: Sunil S. Raikar, et al.
Pubblicazione: (2018-03-01)

NK Cell-Mediated Eradication of Ovarian Cancer Cells with a Novel Chimeric Antigen Receptor Directed against CD44
di: Rüdiger Klapdor, et al.
Pubblicazione: (2021-09-01)

Persistence of tumor-infiltrating CD8 T cells is tumor-dependent but antigen-independent
di: Olurinde, Mobolaji O., et al.
Pubblicazione: (2012)

Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo.
di: Callan, M, et al.
Pubblicazione: (1998)