Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer.

Colorectal cancer (CRC) displays a complex pattern of inheritance. It is postulated that much of the missing heritability of CRC is enshrined in high-impact rare alleles, which are mechanistically and clinically important. In this study, we assay the impact of rare germline mutations on CRC, analysi...

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Bibliographic Details
Main Authors:	Chubb, D, Broderick, P, Dobbins, SE, Frampton, M, Kinnersley, B, Penegar, S, Price, A, Ma, YP, Sherborne, AL, Palles, C, Timofeeva, MN, Bishop, DT, Dunlop, MG, Tomlinson, I, Houlston, RS
Format:	Journal article
Language:	English
Published:	Nature Publishing Group 2016

Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer.

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