Functionalised pyrrolidinones by conjugate addition of stabilised enolates and reformatsky reagents

The α,β-unsaturated lactam 1b has been found to readily undergo conjugate addition reactions with a range of stabilised carbon nucleophiles and Reformatsky reagents under mild conditions in good yield with high diastereoselectivity. This method provides a simple and versatile approach to highly func...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Dyer, J, Keeling, S, Moloney, M
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 1996
Cur síos
Achoimre:The α,β-unsaturated lactam 1b has been found to readily undergo conjugate addition reactions with a range of stabilised carbon nucleophiles and Reformatsky reagents under mild conditions in good yield with high diastereoselectivity. This method provides a simple and versatile approach to highly functionalised pyrrolidinones.