Severe B-cell-mediated CNS disease secondary to alemtuzumab therapy

Alemtuzumab is a pan-lymphocyte depleting anti-CD52 antibody, and is approved as an escalation therapy for patients with multiple sclerosis with active disease defined by clinical or imaging features. In phase 3 clinical trials, the drug was more effective than interferon beta-1a in reducing relapse...

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Bibliographic Details
Main Authors: Haghikia, A, Dendrou, C, Schneider, R, Grüter, T, Postert, T, Matzke, M, Stephanik, H, Fugger, L, Gold, R
Format: Journal article
Language:English
Published: Lancet 2017