Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare (MAF ≤ 1%) variants contribute to complex traits and disease in the general population is mainly unknown. Bone mineral density (BMD) is highly heritable, a major predictor of osteoporotic fractures, and has been p...

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Автори: Zheng, H, Forgetta, V, Hsu, Y-H, Estrada, K, Rosello-Diez, A, Leo, PJ, Dahia, C, Park-Min, K, Tobias, J, Kooperberg, C, Kleinman, A, Styrkarsdottir, U, Liu, C, Uggla, C, Evans, D, Nielson, C, Walter, K, Pettersson-Kymmer, U, McCarthy, S, Eriksson, J, Kwan, T, Jhamai, M, Trajanoska, K, Memari, Y, Min, J, Huang, J, Danecek, P, Wilmot, B, Li, R, Chou, W, Mokry, L, Moayyeri, A, Claussnitzer, M, Cheng, C, Cheung, W, Medina-Gómez, C, Ge, B, Chen, S, Choi, K, Oei, L, Fraser, J, Kraaij, R, Hibbs, M, Gregson, C, Paquette, D, Hofman, A, Wibom, C, Tranah, G, Marshall, M, Gardiner, B, Cremin, K, Auer, P, Hsu, L, Ring, S, Tung, J, Thorleifsson, G, Enneman, A, van Schoor, N, de Groot, L, van der Velde, N, Melin, B, Kemp, J, Christiansen, C, Sayers, A, Zhou, Y, Calderari, S, van Rooij, J, Carlson, C, Peters, U, Berlivet, S, Dostie, J, Uitterlinden, A, Williams, S, Farber, C, Grinberg, D, LaCroix, A, Haessler, J, Chasman, D, Giulianini, F, Rose, L, Ridker, P, Eisman, J, Nguyen, T, Center, J, Nogues, X, Garcia-Giralt, N, Launer, L, Gudnason, V, Mellström, D, Vandenput, L, Amin, N, van Duijn, C, Karlsson, M, Ljunggren, Ö, Svensson, O, Hallmans, G, Rousseau, F, Giroux, S, Bussière, J, Arp, P, Koromani, F, Prince, R, Lewis, J, Langdahl, B, Hermann, A, Jensen, J, Kaptoge, S, Khaw, K, Reeve, J, Formosa, M, Xuereb-Anastasi, A, Åkesson, K, McGuigan, F, Garg, G, Olmos, J, Zarrabeitia, M, Riancho, J, Ralston, S, Alonso, N, Jiang, X, Goltzman, D, Pastinen, T, Grundberg, E, Gauguier, D, Orwoll, E, Karasik, D, Davey-Smith, G, Smith, A, Siggeirsdottir, K, Harris, T, Zillikens, M, van Meurs, J, Thorsteinsdottir, U, Maurano, M, Timpson, N, Soranzo, N, Durbin, R, Wilson, S, Ntzani, E, Brown, M, Stefansson, K, Hinds, D, Spector, T, Cupples, L, Ohlsson, C, Greenwood, C, Jackson, R, Rowe, D, Loomis, C, Ackert-Bicknell, C, Joyner, A, Duncan, E, Kiel, D, Rivadeneira, F, Richards, J
Формат: Journal article
Мова:English
Опубліковано: Nature Publishing Group 2015