Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

<p style="text-align:justify;">Disability or death due to intracerebral hemorrhage (ICH) is attributed to blood lysis, liberation of iron, and consequent oxidative stress. Iron chelators bind to free iron and prevent neuronal death induced by oxidative stress and disability due to I...

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Bibliographic Details
Main Authors: Karuppagounder, S, Alim, I, Khim, S, Bourassa, M, Sleiman, S, John, R, Thinnes, C, Yeh, T, Demetriades, M, Neitemeier, S, Cruz, D, Gazaryan, I, Killilea, D, Morgenstern, L, Xi, G, Keep, R, Schallert, T, Tappero, R, Zhong, J, Cho, S, Maxfield, F, Holman, T, Culmsee, C, Fong, G, Su, Y, Ming, G, Song, H, Cave, J, Schofield, C, Colbourne, F, Coppola, G, Ratan, R
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2016

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