CD28-CD80 Interactions Control Regulatory T Cell Motility and Immunological Synapse Formation.

Regulatory T cells (Tregs) are essential for tolerance to self and environmental Ags, acting in part by downmodulating costimulatory molecules on the surface of dendritic cells (DCs) and altering naive CD4 T cell-DC interactions. In this study, we show that Tregs form stable conjugates with DCs befo...

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Bibliographic Details
Main Authors: Thauland, T, Koguchi, Y, Dustin, M, Parker, D
Format: Journal article
Language:English
Published: American Association of Immunologists 2014