Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance
Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have thus far been disappointing owing to a lack of robust stratification methods. Whole-genome sequencing (WGS) analysis of 129 cases demonstrated that this is a heterogeneous cancer dominated by copy number alterations...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
מחברים אחרים: | |
פורמט: | Journal article |
שפה: | English |
יצא לאור: |
Nature Publishing Group
2016
|