Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance
Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have thus far been disappointing owing to a lack of robust stratification methods. Whole-genome sequencing (WGS) analysis of 129 cases demonstrated that this is a heterogeneous cancer dominated by copy number alterations...
Main Authors: | Secrier, M, Li, X, De Silva, N, Eldridge, MD, Contino, G, Bornschein, J, Macrae, S, Grehan, N, O'Donovan, M, Miremadi, A, Yang, T-P, Bower, L, Chettouh, H, Crawte, J, Galeano-Dalmau, N, Grabowska, A, Saunders, J, Underwood, T, Waddell, N, Barbour, AP, Nutzinger, B, Achilleos, A, Edwards, PAW, Lynch, AG, Tavaré, S, Fitzgerald, RC, Oesophageal Cancer Clinical And Molecular Stratification (Occams) Consortium |
---|---|
Outros autores: | Davies, J |
Formato: | Journal article |
Idioma: | English |
Publicado: |
Nature Publishing Group
2016
|
Títulos similares
-
A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy
por: Noorani, A, et al.
Publicado: (2017) -
The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic
por: Frankell, AM, et al.
Publicado: (2019) -
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas
por: Alvin Wei Tian Ng, et al.
Publicado: (2022-04-01) -
Disentangling oncogenic amplicons in esophageal adenocarcinoma
por: Alvin Wei Tian Ng, et al.
Publicado: (2024-05-01) -
Author Correction: Disentangling oncogenic amplicons in esophageal adenocarcinoma
por: Alvin Wei Tian Ng, et al.
Publicado: (2024-05-01)