Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have thus far been disappointing owing to a lack of robust stratification methods. Whole-genome sequencing (WGS) analysis of 129 cases demonstrated that this is a heterogeneous cancer dominated by copy number alterations...

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Hlavní autoři: Secrier, M, Li, X, De Silva, N, Eldridge, MD, Contino, G, Bornschein, J, Macrae, S, Grehan, N, O'Donovan, M, Miremadi, A, Yang, T-P, Bower, L, Chettouh, H, Crawte, J, Galeano-Dalmau, N, Grabowska, A, Saunders, J, Underwood, T, Waddell, N, Barbour, AP, Nutzinger, B, Achilleos, A, Edwards, PAW, Lynch, AG, Tavaré, S, Fitzgerald, RC, Oesophageal Cancer Clinical And Molecular Stratification (Occams) Consortium
Další autoři: Davies, J
Médium: Journal article
Jazyk:English
Vydáno: Nature Publishing Group 2016

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