A model for all genomes: the role of transcription factories.
A model for all genomes involving one major architectural motif is presented: DNA or chromatin loops are tethered to "factories" through the transcription machinery-a polymerase (active or inactive) or its transcription factors (activators or repressors). These loops appear and disappear a...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826303305524969472 |
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| author | Cook, P |
| author_facet | Cook, P |
| author_sort | Cook, P |
| collection | OXFORD |
| description | A model for all genomes involving one major architectural motif is presented: DNA or chromatin loops are tethered to "factories" through the transcription machinery-a polymerase (active or inactive) or its transcription factors (activators or repressors). These loops appear and disappear as polymerases initiate and terminate (and as factors bind and dissociate), so the structure is ever-changing and self-organizing. This model is parsimonious, detailed (and so easily tested), and incorporates elements found in various other models. |
| first_indexed | 2024-03-07T06:00:39Z |
| format | Journal article |
| id | oxford-uuid:ec11c2e7-e62b-422c-8171-9a0d20720a5d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:00:39Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:ec11c2e7-e62b-422c-8171-9a0d20720a5d2022-03-27T11:14:39ZA model for all genomes: the role of transcription factories.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ec11c2e7-e62b-422c-8171-9a0d20720a5dEnglishSymplectic Elements at Oxford2010Cook, PA model for all genomes involving one major architectural motif is presented: DNA or chromatin loops are tethered to "factories" through the transcription machinery-a polymerase (active or inactive) or its transcription factors (activators or repressors). These loops appear and disappear as polymerases initiate and terminate (and as factors bind and dissociate), so the structure is ever-changing and self-organizing. This model is parsimonious, detailed (and so easily tested), and incorporates elements found in various other models. |
| spellingShingle | Cook, P A model for all genomes: the role of transcription factories. |
| title | A model for all genomes: the role of transcription factories. |
| title_full | A model for all genomes: the role of transcription factories. |
| title_fullStr | A model for all genomes: the role of transcription factories. |
| title_full_unstemmed | A model for all genomes: the role of transcription factories. |
| title_short | A model for all genomes: the role of transcription factories. |
| title_sort | model for all genomes the role of transcription factories |
| work_keys_str_mv | AT cookp amodelforallgenomestheroleoftranscriptionfactories AT cookp modelforallgenomestheroleoftranscriptionfactories |