One-trial tolerance to the effects of chlordiazepoxide on the elevated plus maze may be due to locomotor habituation, not repeated drug exposure.

The phenomenon of "one-trial tolerance" to the effects of chlordiazepoxide hydrochloride (CDP) in the elevated plus maze was re-examined. Unlike previous experiments, pre-exposure to the maze resulted in habituation and a consequential reduction in time spent on the open arms. The habituat...

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Váldodahkkit: Dawson, G, Crawford, S, Stanhope, K, Iversen, S, Tricklebank, MD
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 1994