Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes.
Some viruses, including human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in humans, and lymphocytic choriomeningitis virus (LCMV) in mice, are initially controlled by cytotoxic T lymphocytes (CTLs), but may subsequently escape through mutation of the relevant T-cell epitope. Some of th...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1998
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