The rise and fall of NMDA antagonists for ischemic stroke.

The rise and fall of NMDA antagonists for ischemic stroke.

It has long been accepted that high concentrations of glutamate can destroy neurons, and this is the basis of the theory of excitotoxicity during brain injury such as stroke. Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists such as Selfotel, Aptiganel, Gavestinel and others failed to show...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Hoyte, L, Barber, P, Buchan, A, Hill, MD
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2004

Gelijkaardige items

NMDA antagonists: their role in neuroprotection.
door: Small, D, et al.
Gepubliceerd in: (1997)

NMDA antagonists: their role in neuroprotection.
door: Small, D, et al.
Gepubliceerd in: (1997)

Do NMDA antagonists prevent neuronal injury? No.
door: Buchan, A
Gepubliceerd in: (1992)

AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists?
door: Buchan, A, et al.
Gepubliceerd in: (1993)

The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke.
door: Buchan, A, et al.
Gepubliceerd in: (1992)

Effectiveness of t-PA in acute ischemic stroke: outcome relates to appropriateness.
door: Buchan, A, et al.
Gepubliceerd in: (2000)

Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted?
door: Buchan, A
Gepubliceerd in: (1990)

Biochemistry of ischemic stroke.
door: Barber, P, et al.
Gepubliceerd in: (2003)

Time is brain: Post-marketing experience with alteplase (tPA) for acute ischemic stroke
door: Hill, MD, et al.
Gepubliceerd in: (2000)

Intra-arterial therapy following intravenous alteplase for severe ischemic stroke
door: Hill, MD, et al.
Gepubliceerd in: (2001)

Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction.
door: Xue, D, et al.
Gepubliceerd in: (1994)

POSTISCHEMIC TREATMENT WITH AMPA, BUT NOT NMDA, ANTAGONISTS PREVENTS CA1 NEURONAL INJURY
door: Li, H, et al.
Gepubliceerd in: (1992)

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke.
door: Hill, MD, et al.
Gepubliceerd in: (2000)

Understanding and managing ischemic stroke.
door: Barber, P, et al.
Gepubliceerd in: (2001)

DELAYED TREATMENT WITH AMPA BUT NOT NMDA GLUTAMATE ANTAGONISTS REDUCES NEOCORTICAL INFARCTION
door: Xue, D, et al.
Gepubliceerd in: (1992)

Improved regional cerebral blood flow is important for the protection seen in a mouse model of late phase ischemic preconditioning.
door: Hoyte, L, et al.
Gepubliceerd in: (2006)

Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study.
door: Hill, MD, et al.
Gepubliceerd in: (2005)

HYPOTHERMIA BUT NOT NMDA RECEPTOR ANTAGONIST MK-801 ATTENUATES NEURON DAMAGE - ARE THE RESULTS CONCLUSIVE - REPLY
door: Buchan, A, et al.
Gepubliceerd in: (1992)

Neuroprotection, excitotoxicicity and nmda antagonists
door: RUBENS JOSÉ GAGLIARDI
Gepubliceerd in: (2000-06-01)

Animal Models of Stroke
door: Hoyte, L, et al.
Gepubliceerd in: (2010)

Organised stroke care increases the numbers and the speed with which patients with acute ischemic stroke are thrombolysed
door: Kennedy, J, et al.
Gepubliceerd in: (2002)

Is alteplase safe and effective in routine clinical practice for patients with ischemic stroke?
door: Buchan, A, et al.
Gepubliceerd in: (2007)

Building a "brain attack" team to administer thrombolytic therapy for acute ischemic stroke.
door: Hill, MD, et al.
Gepubliceerd in: (2000)

NMDA Receptor Antagonists for Treatment of Depression
door: Zeynep Ates-Alagoz, et al.
Gepubliceerd in: (2013-04-01)

Effectiveness of tissue-type plasminogen activator for acute ischemic stroke: Consequences of protocol violation
door: Karbalai, H, et al.
Gepubliceerd in: (1999)

NEUROPROTECTIVE PROFILE OF FPL-15896AR, A NOVEL UNCOMPETITIVE NMDA ANTAGONIST
door: Murray, R, et al.
Gepubliceerd in: (1995)

Opioid Antagonist in the Treatment of Ischemic Stroke
door: Juan Fernando Ortiz, et al.
Gepubliceerd in: (2021-06-01)

Outcomes of thrombolysis for acute ischemic stroke in octogenarians versus nonagenarians.
door: Mateen, F, et al.
Gepubliceerd in: (2010)

THE NMDA RECEPTOR-ION CHANNEL - ITS IMPORTANCE TO INVIVO ISCHEMIC-INJURY TO SELECTIVELY VULNERABLE NEURONS
door: Pulsinelli, W, et al.
Gepubliceerd in: (1990)

Correction: Diagnostic Potential of the NMDA Receptor Peptide Assay for Acute Ischemic Stroke.
door: Svetlana A Dambinova, et al.
Gepubliceerd in: (2013-01-01)

Informed consent for thrombolytic therapy in acute ischemic stroke.
door: Sivakumar, C, et al.
Gepubliceerd in: (2005)

Acute ischaemic stroke. Thrombolysis for acute ischaemic stroke works.
door: Hill, MD, et al.
Gepubliceerd in: (2000)

NMDA receptor antagonists in the treatment of neurological diseases
door: I. S. Preobrazhenskaya
Gepubliceerd in: (2020-10-01)

PSYCHOPHARMACOLOGICAL PROFILE OF THE NMDA RECEPTOR ANTAGONIST MK-801
door: Iversen, S, et al.
Gepubliceerd in: (1987)

Thrombolytic therapy for acute ischemic stroke - The CAEP Position Statement: another perspective.
door: Hill, MD, et al.
Gepubliceerd in: (2001)

Antagonism of the NMDA and non-NMDA receptors in global versus focal brain ischemia.
door: Pulsinelli, W, et al.
Gepubliceerd in: (1993)

Early T1- and T2-weighted MRI signatures of transient and permanent middle cerebral artery occlusion in a murine stroke model studied at 9.4T.
door: Barber, P, et al.
Gepubliceerd in: (2005)

Cold Pain Threshold and Role of NMDA Receptor Antagonists
door: Poroshat Nazemi, et al.
Gepubliceerd in: (2019-01-01)

Thrombolysis for acute ischemic stroke in patients older than 80 years
door: N, S, et al.
Gepubliceerd in: (2006)

The Canadian activase for stroke effectiveness study (CASES)
door: Hill, MD, et al.
Gepubliceerd in: (2000)