Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether–lumefantrine and artesunate–amodiaquine in Africa

Artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ) are the most commonly used artemisinin-based combination therapies (ACT) for treatment of Plasmodium falciparum in Africa. Both treatments remain efficacious, but single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum multi...

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Detalles Bibliográficos
Main Authors: Okell, L, Reiter, L, Ebbe, L, Baraka, V, Bisanzio, D, Watson, O, Bennett, A, Verity, R, Gething, P, Roper, C, Alifrangis, M
Formato: Journal article
Idioma:English
Publicado: BMJ Publishing Group 2018