Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates early gliomagenesis

Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates early gliomagenesis

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Isocitrate dehydrogenase 1 mutations drive human gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this disease, we conditionally expressed Idh1^R132H in the subventricular zone (SVZ) of the adult mouse brain. The mice developed hydro...

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Bibliographic Details
Main Authors: Bardella, C, Al-Dalahmah, O, Krell, D, Brazauskas, P, Tomkova, M, Adam, J, Serres, S, Lockstone, H, Freeman-Mills, L, Pfeffer, I, Sibson, N, Goldin, R, Schuster-Böeckler, B, Pollard, P, Soga, T, McCullagh, J, Schofield, C, Mulholland, P, Ansorge, O, Kriaucionis, S, Ratcliffe, P, Szele, F, Tomlinson, I, Al-Qahtani, K
Format: Journal article
Published: Elsevier 2016

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