Inhibition of HIV-1 replication by ribozymes that show poor activity in vitro.
Self-cleaving RNAs (ribozymes) can be engineered to cleave target RNAs of choice in a sequence-specific manner (1). Consequently, they could be used to inhibit virus replication or to analyse host gene function in vivo. However, ribozymes that are catalytic in vitro are generally disappointing when...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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